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Diflucan vs cream ) or oral placebo). Outcomes in women were analyzed using Wilcoxon rank-sum tests. Differences of baseline characteristics and blood parameters between the two arms were compared by analysis of covariance. Women assigned to the study had significantly higher systolic blood pressure (P <.01 after Bonferroni post hoc analysis) and diastolic blood pressure (P <.05) than where can you buy diflucan over the counter control women after treatment initiation. Blood pressure remained significantly higher at follow-up (P <.05) after treatment in the LNG-supplemented group, but not placebo group (P =.11). The proportion of patients with hypertension decreased over time in both treatment groups; by the fourth trial visit, 28.8% of control women and 22.5% LNG-supplemented had hypertension, by 24 weeks, 37.8% (1.7-62.9%) and 33.1% (1.4-61.4%), respectively (Table). Women who continued to consume LNG capsules at trial weeks 4 and 12 had a significantly lower risk of hypertension than women who did not receive LNG capsules (Table), and the difference persisted after adjustment for age, BMI, smoking status, and physical activity level. The hazard ratios of hypertension were 0.76 (95% CI, 0.65-0.90. P =.006) and 0.66 (95% CI, 0.50-0.83), respectively, for women in the LNG-supplemented treatment group compared with the placebo (after Bonferroni post hoc analysis), with the latter finding remaining significant (P =.0002) after adjustment for age, BMI, and smoking status. Comment The majority of women consumed LNG capsules during study visits at least once. The use of LNG capsules for over a year significantly reduced the incidence of hypertension among nonhypertensive women. Previous long-term trials of LNG capsules showed that they had no effect on blood pressure at the beginning of trial but did reduce it by 4 weeks (10). However, these trials included only women with high baseline blood pressure. This trial included an older population and a substantial number of women with hypertension. Additionally, an association has been reported between the use of LNG capsules and increased risk of heart disease and stroke (11,13). We have also shown that LNG supplementation reduced mean arterial pressure in patients with preexisting hypertension. Hypertension, as indicated by a systolic blood pressure greater than 160 mm Hg and diastolic blood pressure greater than 90 mm Hg, is a major risk factor for stroke but may also be associated with increased risk for heart failure, myocardial infarction, angina pectoris, or congestive heart failure (14). Hypertension might also be an important factor in the development of cardiovascular events (15). Thus, we would expect that reducing the risk of stroke in women with hypertension should reduce the incidence of myocardial infarction, angina pectoris, and congestive heart failure. To our knowledge, this is the first long-term uncontrolled trial, to our knowledge, in which LNG has been studied as a treatment for hypertension in women. We have shown that the incidence of hypertension was reduced from a mean of 46.8% among the placebo group at 2 weeks to 29.9% among the women who initiated LNG therapy Buy diflucan 150 mg online between weeks 4 and 12. Although a large body of evidence suggests that LNG reduces blood pressure, the specific mechanism responsible and effect on the overall response to a treatment are less clearly elucidated. We have shown that the LNG group saw a marked reduction in mean systolic and diastolic blood pressures at week 12, whereas the LNG-supplemented independent pharmacy association canada group did not. This result suggests that the LNG group was able to maintain pressure control before the initiation of therapy, presumably because it had taken into account and adjusted for the effects of lifestyle and lifestyle-related factors. Two important points to bear in mind are that the LNG treatment appeared to make a substantial initial difference, then had a gradual but clinically significant decline in control from weeks 4 to 8, and was significantly lower after week 24. We are not certain whether or to what extent LNG may have changed other clinical parameters beyond blood pressure. However, it was found that the LNG group had significantly lower mean body weight, BMI, and higher mean body fat before the study than control group. Thus, it is unlikely that the LNG capsule had any effect, and perhaps even had the opposite effect, on diet and activity. This trial provides an interesting demonstration of the effect LNG supplementation on blood pressure, both at follow-up and long term. This study provides further evidence to support the beneficial effect that LNG capsules have on blood pressure, and it will be of interest to.
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